Article
Influence of MILR1 promoter polymorphism on expression levels and the phenotype of atopy.
Journal of human genetics - 1 Sept 2014
Nanatsue Kentaro, Ninomiya Takahiro, Tsuchiya Mio, Tahara-Hanaoka Satoko, Shibuya Akira, Masuko Hironori, Sakamoto Toru, Hizawa Nobuyuki, Arinami Tadao, Noguchi Emiko
Abstract excerpt
The recently identified cell surface immunoreceptor MILR1 (mast cell immunoglobulin-like receptor 1; synonyms, Allergin-1) has been shown to suppress immunoglobulin E (IgE)-mediated, mast cell-dependent responses in both mice and humans. We performed a mutation search of MILR1 together with a genetic association study to determine whether polymorphisms in MILR1 are associated with atopy in human. Mutation...
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