Article
DBH -1021C-->T does not modify risk or age at onset in Parkinson's disease.
Annals of neurology - 1 Jul 2007
Chun Lani S, Samii Ali, Hutter Carolyn M, Griffith Alida, Roberts John W, Leis Berta C, Mosley Anthony D, Wander P Luke, Edwards Karen L, Payami Haydeh, Zabetian Cyrus P
Abstract excerpt
DBH is a candidate gene in Parkinson's disease (PD) and contains a putative functional polymorphism (-1021C-->T) that has been reported to modify PD susceptibility. We examined -1021C-->T in a sample of 1,244 PD patients and 1,186 unrelated control subjects. There was no significant difference in allele (p = 0.14) or genotype (p = 0.26) frequencies between the two groups. A similar result was obtained after...
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