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Article

In vitro erythropoiesis from bone marrow-derived progenitors provides a physiological assay for toxic and mutagenic compounds.

Proceedings of the National Academy of Sciences of the United States of America - 22 May 2007

Shuga J, Zhang J, Samson L D, Lodish H F, Griffith L G

Abstract excerpt

The goal of this study was to create an in vitro cell culture system that captures essential features of the in vivo erythroid micronucleus (MN) genotoxicity assay, thus enabling increased throughput and controlled studies of the hematopoietic DNA damage response. We show that adult bone marrow (BM) cultures respond to erythropoietin, the principal hormone that stimulates erythropoiesis, with physiological...

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Identifiers

PMID: 17502613
DOI: 10.1073/pnas.0701829104
PMCID: PMC1885572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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