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Article

Acquired DNA mutations associated with in vivo hydroxyurea exposure

1 Jun 2000

Abstract excerpt

Hydroxyurea (HU) is an effective therapeutic agent for patients with myeloproliferative disorders (MPDs) or sickle cell disease (SCD). Short-term HU toxicities primarily include transient myelosuppression, but long-term HU risks have not been defined. The mutagenic and carcinogenic potential of HU is not established, although HU has been associated with an increased risk of leukemia in some patients with MPD. In...

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PMID: 10828048
DOI: 10.1182/blood.v95.11.3589

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