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MUC1-C Oncoprotein Promotes STAT3 Activation in an Autoinductive Regulatory Loop

15 Feb 2011

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) is activated in human breast cancer and other malignancies. Mucin 1 (MUC1) is a heterodimeric cell surface glycoprotein that is overexpressed in human carcinomas and, like STAT3, promotes cell survival and induces transformation. We found that in breast cancer cells, the MUC1 carboxyl-terminal receptor subunit (MUC1-C) associates with the...

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PMID: 21325207
DOI: 10.1126/scisignal.2001426

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