Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Leber congenital amaurosis protein AIPL1 modulates the nuclear translocation of NUB1 and suppresses inclusion formation by NUB1 fragments.

The Journal of biological chemistry - 12 Nov 2004

van der Spuy Jacqueline, Cheetham Michael E

Abstract excerpt

Mutations in the aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) cause the blinding disease Leber congenital amaurosis (LCA). The similarity of AIPL1 to AIP has led to suggestions that AIPL1 could function in a similar manner to AIP in facilitating protein translocation and as a component of chaperone complexes. AIPL1 interacts with the cell cycle regulator NEDD8 ultimate buster protein 1 (NUB1). As...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Adaptor Proteins, Signal Transducing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carrier Proteins

Share to Eye Proteins

Share to Inclusion Bodies

Share to Optic Atrophy, Hereditary, Leber

Share to Peptide Fragments

Share to Recombinant Fusion Proteins

Source

Identifiers

PMID: 15347646
DOI: 10.1074/jbc.M407871200

Genes

NUB1
AIPL1
AIP
NEDD8
SDS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Leber congenital amaurosis protein AIPL1 modulates the nuclear translocation of NUB1 and suppresses inclusion formation by NUB1 fragments.PMID 15347646Read ↗

The inherited blindness associated protein AIPL1 interacts with the cell cycle regulator protein NUB1.Semantic proximity Read ↗

The Leber congenital amaurosis protein AIPL1 functions as part of a chaperone heterocomplex.Semantic proximity Read ↗

The inherited blindness protein AIPL1 regulates the ubiquitin-like FAT10 pathway.Semantic proximity Read ↗

The Expression of the Leber Congenital Amaurosis Protein AIPL1 Coincides with Rod and Cone Photoreceptor DevelopmentSemantic proximity Read ↗

Predominant rod photoreceptor degeneration in Leber congenital amaurosis.Semantic proximity Read ↗

Cytoplasmic targeting of mutant poly(A)-binding protein nuclear 1 suppresses protein aggregation and toxicity in oculopharyngeal muscular dystrophy.Semantic proximity Read ↗

The Leber congenital amaurosis gene product AIPL1 is localized exclusively in rod photoreceptors of the adult human retinaSemantic proximity Read ↗

Purification, characterisation and intracellular localisation of aryl hydrocarbon interacting protein-like 1 (AIPL1) and effects of mutations associated with inherited retinal dystrophies.Semantic proximity Read ↗

Leber congenital amaurosis linked to AIPL1: a mouse model reveals destabilization of cGMP phosphodiesterase.Semantic proximity Read ↗

The integrity and organization of the human AIPL1 functional domains is critical for its role as a HSP90-dependent co-chaperone for rod PDE6.Semantic proximity Read ↗

Investigation of Aberrant Splicing Induced byAIPL1Variations as a Cause of Leber Congenital AmaurosisSemantic proximity Read ↗

Mutations in nucleoporins and their roles in human diseases: Integrating evidence on specific NUP functions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.