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Article

Modulating Autophagy for Therapeutic Benefit

20 Sept 2007

Abstract excerpt

Autophagy is an ancient cell survival pathway that allows cells to recoup ATP and essential building blocks for biosynthesis when they are starved of nutrients or when they are exposed to hypoxia, which are hallmarks of the tumor microenvironment. This pathway involves the formation of double-membraned vesicles, coined autophagosomes, which envelop bulk cellular material and/or organelles and that subsequently...

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PMID: 17495516
DOI: 10.4161/auto.4311

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