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Autophagy induction by Bcr‐Abl‐expressing cells facilitates their recovery from a targeted or nontargeted treatment

27 Oct 2010

Abstract excerpt

Although Imatinib has transformed the treatment of chronic myeloid leukemia (CML), it is not curative due to the persistence of resistant cells that can regenerate the disease. We have examined how Bcr-Abl-expressing cells respond to two mechanistically different therapeutic agents, etoposide and Imatinib. We also examined Bcr-Abl expression at low and high levels as elevated expression has been associated with...

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PMID: 21132731
DOI: 10.1002/ajh.21914

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