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Article

LRH‐1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance

8 Jul 2022

Abstract excerpt

Nuclear receptors are transcription factors with important functions in a variety of physiological and pathological processes. Targeting glucocorticoid receptor (GR) activity using glucocorticoids is a cornerstone in the treatment of patients with T cell acute lymphoblastic leukemia (T-ALL), and resistance to GC-induced cell death is associated with poor outcome and a high risk for relapse. Next to...

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PMID: 35801407
DOI: 10.15252/embr.202154195

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