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Article

The W101C KCNJ5 Mutation Induces Slower Pacing by Constitutively Active GIRK Channels in hiPSC-Derived Cardiomyocytes.

International journal of molecular sciences - 18 Oct 2023

Kayser Anne, Dittmann Sven, Šarić Tomo, Mearini Giulia, Verkerk Arie O, Schulze-Bahr Eric

Abstract excerpt

Mutations in the KCNJ5 gene, encoding one of the major subunits of cardiac G-protein-gated inwardly rectifying K+ (GIRK) channels, have been recently linked to inherited forms of sinus node dysfunction. Here, the pathogenic mechanism of the W101C KCNJ5 mutation underlying sinus bradycardia in a patient-derived cellular disease model of sinus node dysfunction (SND) was investigated. A human-induced pluripotent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37894977
DOI: 10.3390/ijms242015290
PMCID: PMC10607318

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