Article
Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure.
The Biochemical journal - 15 Nov 2014
Corral-Rodríguez María Ángeles, Stuiver Marchel, Abascal-Palacios Guillermo, Diercks Tammo, Oyenarte Iker, Ereño-Orbea June, de Opakua Alain Ibáñez, Blanco Francisco J, Encinar José Antonio, Spiwok Vojtêch, Terashima Hiroyuki, Accardi Alessio, Müller Dominik, Martínez-Cruz Luis Alfonso
Abstract excerpt
Recent studies suggest CNNM2 (cyclin M2) to be part of the long-sought basolateral Mg2+ extruder at the renal distal convoluted tubule, or its regulator. In the present study, we explore structural features and ligand-binding capacities of the Bateman module of CNNM2 (residues 429-584), an intracellular domain structurally equivalent to the region involved in Mg2+ handling by the bacterial Mg2+ transporter MgtE,...
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