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Article

Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters.

Structure (London, England : 1993) - 2 Jun 2020

Acar Burçin, Rose Jessica, Aykac Fas Burcu, Ben-Tal Nir, Lewinson Oded, Haliloglu Turkan

Abstract excerpt

ABC transporters couple the energy of ATP hydrolysis to the transmembrane transport of biomolecules. Here, we investigated the allosteric networks of three representative ABC transporters using a hybrid molecular simulations approach validated by experiments. Each of the three transporters uses a different allosteric network: in the constitutive B12 importer BtuCD, ATP binding is the main driver of allostery and...

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Identifiers

PMID: 32320672
DOI: 10.1016/j.str.2020.03.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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