Article

Modeling the MYC-driven normal-to-tumour switch in breast cancer

2018-07-31

Abstract excerpt

<h4>ABSTRACT</h4> The potent MYC oncoprotein is deregulated in many human cancers, including breast carcinoma, and is associated with aggressive disease. To understand the mechanisms and vulnerabilities of MYC-driven breast cancer, we have generated an in vivo model that mimics human disease in response to MYC deregulation. MCF10A cells ectopically expressing a common breast cancer mutation in the PI3 kinase pat...

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Literature Corpus work: ca9c10d7-72b8-58b4-a859-165f9f716ed5
DOI: 10.1101/380931

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