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Telomere Biology and Human Phenotype

19 Jan 2019

Abstract excerpt

Telomeres are nucleoprotein structures that cap the end of each chromosome arm and function to maintain genome stability. The length of telomeres is known to shorten with each cell division and it is well-established that telomere attrition is related to replicative capacity in vitro. Moreover, telomere loss is also correlated with the process of aging in vivo. In this review, we discuss the mechanisms that lead...

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PMID: 30669451
DOI: 10.3390/cells8010073

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