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Article

HIV-1 escape from the entry-inhibiting effects of a cholesterol-binding compound via cleavage of gp41 by the viral protease.

Proceedings of the National Academy of Sciences of the United States of America - 15 May 2007

Waheed Abdul A, Ablan Sherimay D, Roser James D, Sowder Raymond C, Schaffner Carl P, Chertova Elena, Freed Eric O

Abstract excerpt

HIV-1 virions are highly enriched in cholesterol relative to the cellular plasma membrane. We recently reported that a cholesterol-binding compound, amphotericin B methyl ester (AME), blocks HIV-1 entry and that single amino acid substitutions in the cytoplasmic tail of the transmembrane envelope glycoprotein gp41 confer resistance to AME. In this study, we defined the mechanism of resistance to AME. We observed...

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Identifiers

PMID: 17483482
DOI: 10.1073/pnas.0701443104
PMCID: PMC1895973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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