Maturation-dependent human immunodeficiency virus type 1 particle fusion requires a carboxyl-terminal region of the gp41 cytoplasmic tail.

doi:10.1128/JVI.00592-07

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Article

Maturation-dependent human immunodeficiency virus type 1 particle fusion requires a carboxyl-terminal region of the gp41 cytoplasmic tail.

Journal of virology - 1 Sept 2007

Jiang Jiyang, Aiken Christopher

Abstract excerpt

Lentiviruses, including human immunodeficiency virus type 1 (HIV-1), typically encode fusion glycoproteins with long cytoplasmic tails (CTs). We previously reported that immature HIV-1 particles are inhibited for fusion with target cells by a mechanism requiring the 152-amino-acid CT of gp41. The gp41 CT was also shown to mediate the detergent-resistant association of the HIV-1 envelope glycoprotein complex with...

Topics

Gene Products, gag
HIV Envelope Protein gp41
HIV-1
Humans
Mutation
Protein Binding
Protein Structure, Tertiary
Virion
Virus Assembly
Virus Internalization

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Identifiers

PMID: 17609279
DOI: 10.1128/JVI.00592-07
PMCID: PMC2045384

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