Article
Inducible nitric oxide synthase promoter polymorphism, cigarette smoking, and urothelial carcinoma risk.
Urology - 1 May 2007
Shen Cheng-Huang, Wang Yuan-Hung, Wang Wen-Chuang, Jou Yeong-Chin, Hsu Hueih-Shing, Hsieh Hsiao-Yen, Chiou Hung-Yi
Abstract excerpt
OBJECTIVES: Bladder carcinoma has a high inducible nitric oxide synthase (iNOS) content, and a highly polymorphic (CCTTT)n repeat in the iNOS promoter region has been identified. We explored whether this iNOS promoter polymorphism and cigarette smoking are associated with urothelial carcinoma (UC) risk. METHODS: A total of 250 patients with pathologically confirmed UC and 250 unrelated noncancer controls were...
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