Article
A novel genetic polymorphism of inducible nitric oxide synthase is associated with an increased risk of gastric cancer.
World journal of gastroenterology - 15 Nov 2004
Shen Jing, Wang Run-Tian, Wang Li-Wei, Xu Yao-Chu, Wang Xin-Ru
Abstract excerpt
AIM: Inducible nitric oxide synthase (iNOS) plays a central role in the pathway of reactive oxygen and nitrogen species metabolism when Helicobacter pylori (H pylori) infection occurs in humans. iNOS Ser(608)Leu allele, a novel genetic polymorphism (C/T) occurring within exon 16 of the iNOS reductase domain, may have a dramatic effect on the enzymatic activity. The aim of this study was to determine whether iNOS...
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