Article
hTERT (-1327)T/C polymorphism is not associated with age-related telomere attrition in peripheral blood.
Biochemical and biophysical research communications - 22 Jun 2007
Nordfjäll Katarina, Osterman Pia, Melander Olle, Nilsson Peter, Roos Göran
Abstract excerpt
Regulation of the telomerase catalytic subunit, hTERT, is a complex process accomplished on many levels. Transcription of the hTERT gene has been widely studied but less is known about the implication of genetic variations. Recently, a functional T to C transition polymorphism was indicated 1327 bp upstream the hTERT transcription starting site. The (-1327)C/C genotype was associated with shorter telomere length...
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