Article
Association of genetic variation in telomere-related SNP and telomerase with ventricular arrhythmias in ischemic cardiomyopathy.
Pacing and clinical electrophysiology : PACE - 1 Mar 2018
Sawhney Vinit, Brouilette Scott, Campbell Niall, Coppen Steven, Baker Victoria, Hunter Ross, Dhinoja Mehul, Johnston Atholl, Earley Mark, Sporton Simon, Suzuki Ken, Schilling Richard
Abstract excerpt
BACKGROUND: Telomeres are known to provide genomic stability and telomere length has been associated with cardiovascular diseases. Moreover, a higher telomerase activity has been shown to be associated with ventricular arrhythmias (VA) in ischemic cardiomyopathy. Increasing evidence suggests that genetic variation in key telomere genes has an impact on telomerase activity. Each copy of the minor allele of SNP...
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