Article
Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation.
The Journal of biological chemistry - 29 Jun 2007
Pillinger Michael H, Marjanovic Nada, Kim Seok-Yong, Lee Yong-Chan, Scher Jose U, Roper Jatin, Abeles Aryeh M, Izmirly Peter I, Axelrod Matthew, Pillinger Mara Y, Tolani Sonia, Dinsell Victoria, Abramson Steven B, Blaser Martin J
Abstract excerpt
Because the mechanisms of Helicobacter pylori-induced gastric injury are incompletely understood, we examined the hypothesis that H. pylori induces matrix metalloproteinase-1 (MMP-1) secretion, with potential to disrupt gastric stroma. We further tested the role of CagA, an H. pylori virulence fa...
Topics
- Antigens, Bacterial
- Bacterial Proteins
- Cell Line, Tumor
- Epithelial Cells
- Extracellular Signal-Regulated MAP Kinases
- Genotype
- Helicobacter Infections
- Helicobacter pylori
- Humans
- MAP Kinase Signaling System
- Matrix Metalloproteinase 1
- Neoplasms, Glandular and Epithelial