Article
Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and -independent ERK activation.
The Journal of biological chemistry - 29 Jun 2007
Pillinger Michael H, Marjanovic Nada, Kim Seok-Yong, Lee Yong-Chan, Scher Jose U, Roper Jatin, Abeles Aryeh M, Izmirly Peter I, Axelrod Matthew, Pillinger Mara Y, Tolani Sonia, Dinsell Victoria, Abramson Steven B, Blaser Martin J
Abstract excerpt
Because the mechanisms of Helicobacter pylori-induced gastric injury are incompletely understood, we examined the hypothesis that H. pylori induces matrix metalloproteinase-1 (MMP-1) secretion, with potential to disrupt gastric stroma. We further tested the role of CagA, an H. pylori virulence factor, in MMP-1 secretion. Co-incubation of AGS cells with Tx30a, an H. pylori strain lacking the cagA virulence gene,...
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