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Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier

1 May 2008

Abstract excerpt

BACKGROUND: Methotrexate (MTX) uptake is mediated by the reduced folate carrier (RFC). Defective drug uptake in association with decreased RFC expression is a common mechanism of MTX resistance in many tumor types. Heavy promoter methylation was previously identified as a basis for the complete silencing of RFC in MDA-MB-231 breast cancer cells, its role and prevalence in RFC transcription regulation are,...

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PMID: 18452618
DOI: 10.1186/1471-2407-8-124

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