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Article

Immortalization of human urothelial cells by human papillomavirus type 16 E6 and E7 genes in a defined serum-free system.

Cell proliferation - 1 Apr 2007

Carmean N, Kosman J W, Leaf E M, Hudson A E, Opheim K E, Bassuk J A

Abstract excerpt

UNLABELLED: Normal human epithelial cell cultures exhibit a limited (although different between tissues) lifespan in vitro. In previous studies, urothelial cell cultures were immortalized using retroviral transformation with human papillomavirus type 16 E6 and E7 genes, in undefined culture systems containing serum or bovine pituitary extract. OBJECTIVE: Due to the variability of results in such systems, we...

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Identifiers

PMID: 17472725
DOI: 10.1111/j.1365-2184.2007.00428.x
PMCID: PMC6495660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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