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Article

Improved mutation detection in GC-rich DNA fragments by combined DGGE and CDGE.

Nucleic acids research - 1 Aug 1999

Wu Y, Stulp R P, Elfferich P, Osinga J, Buys C H, Hofstra R M

Abstract excerpt

Denaturing gradient gel electrophoresis (DGGE) has proven to be a powerful pre-screening method for the detection of DNA variants. If such variants occur, however, in DNA fragments that are very rich in G and C, they may escape detection. To overcome this limitation, we tested a novel gel system which combines DGGE and constant denaturant gel electrophoresis (CDGE), as it might have the advantages of both...

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Identifiers

PMID: 10454628
DOI: 10.1093/nar/27.15.e9
PMCID: PMC148520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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