Article
Association of ET-1 gene polymorphisms with COPD phenotypes in a Caucasian population.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace - 1 Jun 2011
Kaparianos A, Sampsonas F, Lykouras D, Efremidis G, Drakatos P, Karkoulias K, Gogos C, Spiropoulos K
Abstract excerpt
BACKGROUND AND AIM: The phenotypic expression of COPD consists of pulmonary emphysema and chronic bronchitis. An imprecise phenotypic definition may result in inconsistencies among genetic studies regarding COPD pathogenesis. Endothelin-1 gene polymorphisms have been linked to increased susceptibility of COPD development. The present study examined the involvement of +138 insA/delA and G198T ET-1 polymorphisms...
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