Article
EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity.
Physiological genomics - 3 Mar 2010
Darrah Rebecca, McKone Edward, O'Connor Clare, Rodgers Christine, Genatossio Alan, McNamara Sharon, Gibson Ronald, Stuart Elborn J, Ennis Madeleine, Gallagher Charles G, Kalsheker Noor, Aitken Moira, Wiese Dawn, Dunn John, Smith Paul, Pace Rhonda, Londono Douglas, Goddard Katrina A B, Knowles Michael R, Drumm Mitchell L
Abstract excerpt
Airway inflammation and pulmonary disease are heterogeneous phenotypes in cystic fibrosis (CF) patients, even among patients with the same cystic fibrosis transmembrane conductance regulator (CFTR) genotype. Endothelin, a proinflammatory peptide and smooth muscle agonist, is increased in CF airways, potentially contributing to the pulmonary phenotype. Four cohorts of CF patients were screened for variants in...
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