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Article

Paraoxonase 1 gene polymorphisms in patients with osteonecrosis of the femoral head with and without cerebral white matter lesions.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Aug 2007

Hadjigeorgiou Georgios M, Malizos Konstantinos, Dardiotis Efthimios, Aggelakis Konstantinos, Dardioti Maria, Zibis Aristidis, Dimitroulias Apostolos, Scarmeas Nikolaos, Tsezou Aspasia, Karantanas Apostolos

Abstract excerpt

Cerebral white matter lesions (WML) are present in more than 50% of patients with osteonecrosis of the femoral head (ONFH). Paraoxonase 1 (PON1) gene product is a detoxifying and pesticide metabolizing enzyme. Genetic variants of the PON1 gene have been found to influence the occurrence and progr...

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Identifiers

PMID: 17469180
DOI: 10.1002/jor.20393

Genes

PON1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17469180-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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