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Article

PPARGC1B Is Associated with Nontraumatic Osteonecrosis of the Femoral Head: A Genomewide Association Study on a Chart-Reviewed Cohort.

The Journal of bone and joint surgery. American volume - 16 Sept 2020

Zhang Yanfei, Bowen Thomas R, Lietman Steven A, Suk Michael, Williams Marc S, Lee Ming Ta Michael

Abstract excerpt

BACKGROUND: Previous studies have demonstrated the influence of heritable factors on the development of nontraumatic osteonecrosis of the femoral head (ONFH). We hypothesized that genetic variation is associated with an increased risk of ONFH, and that variants could be identified by a genomewide association study (GWAS). METHODS: Using data collected from the MyCode Community Health Initiative, we identified 118...

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Identifiers

PMID: 32701715
DOI: 10.2106/JBJS.19.01335

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