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Article

Trafficking Dynamics of PCSK9-Induced LDLR Degradation: Focus on Human PCSK9 Mutations and C-Terminal Domain.

PloS one - 1 Jan 2016

Poirier Steve, Hamouda Hocine Ait, Villeneuve Louis, Demers Annie, Mayer Gaétan

Abstract excerpt

PCSK9 is a secreted ligand and negative post-translational regulator of low-density lipoprotein receptor (LDLR) in hepatocytes. Gain-of-function (GOF) or loss-of-function (LOF) mutations in PCSK9 are directly correlated with high or low plasma LDL-cholesterol levels, respectively. Therefore, PCSK9 is a prevailing lipid-lowering target to prevent coronary heart diseases and stroke. Herein, we fused monomeric...

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Topics

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Share to PCSK9 gene
Share to Hep G2 Cells
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proprotein Convertase 9

Share to Protein Domains

Share to Protein Transport

Share to Proteolysis

Share to Receptors, LDL

Source

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Identifiers

PMID: 27280970
DOI: 10.1371/journal.pone.0157230
PMCID: PMC4900664

Genes

PCSK9
LDLR

Variants

Provenance

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