Treatment with risperidone for 4 weeks increased plasma 3-methoxy-4-hydroxypnenylglycol (MHPG) levels, but did not alter plasma brain-derived neurotrophic factor (BDNF) levels in schizophrenic patients.

doi:10.1016/j.pnpbp.2007.03.010

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Treatment with risperidone for 4 weeks increased plasma 3-methoxy-4-hydroxypnenylglycol (MHPG) levels, but did not alter plasma brain-derived neurotrophic factor (BDNF) levels in schizophrenic patients.

Progress in neuro-psychopharmacology & biological psychiatry - 30 Jun 2007

Yoshimura Reiji, Hori Hikaru, Sugita Atsuko, Ueda Nobuhisa, Kakihara Shingo, Umene Wakako, Nakano Yuichiro, Shinkai Koji, Mitoma Masae, Ohta Makiko, Shinkai Takahiro, Nakamura Jun

Abstract excerpt

In the present study, we investigated the effects of risperidone treatment for 4 weeks on plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) and brain-derived neurotrophic factor (BDNF) in 89 schizophrenic patients. We also compared the plasma levels of BDNF and MHPG between the schizophrenic group and 103 sex-and age-matched normal controls. In addition, we investigated the effects of two SNPs of the...

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Treatment with risperidone for 4 weeks increased plasma 3-methoxy-4-hydroxypnenylglycol (MHPG) levels, but did not alter plasma brain-derived neurotrophic factor (BDNF) levels in schizophrenic patients.

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