Serum concentrations and side effects in psychiatric patients during risperidone therapy.

doi:10.1097/00007691-199808000-00004

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Article

Serum concentrations and side effects in psychiatric patients during risperidone therapy.

Therapeutic drug monitoring - 1 Aug 1998

Olesen O V, Licht R W, Thomsen E, Bruun T, Viftrup J E, Linnet K

Abstract excerpt

Steady state serum concentrations of risperidone and 9-hydroxyrisperidone (9-OH-risperidone), the active moiety, were measured in 42 patients. The concentration-to-dose ratios (C/D) varied by a factor of 20, from 1.8 to 36.8 (nmol/l)/(mg/24 hours), and 90% of the active moiety was constituted of...

Topics

Adult
Aged
Antipsychotic Agents
Cross-Sectional Studies
Cytochrome P-450 CYP2D6
Drug Interactions
Female
Genotype
Humans
Isoxazoles
Male
Middle Aged
Paliperidone Palmitate
Psychotropic Drugs
Pyrimidines
Risperidone

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