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Article

Cytochrome P450 3A inhibitor itraconazole affects plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients.

Clinical pharmacology and therapeutics - 1 Nov 2005

Jung Sun Min, Kim Kyoung-Ah, Cho Hyun-Kee, Jung Il Geun, Park Pil-Whan, Byun Won Tan, Park Ji-Young

Abstract excerpt

BACKGROUND AND OBJECTIVE: Despite the belief that cytochrome P450 (CYP) 2D6 alone is responsible for the metabolism of risperidone, several studies suggest that CYP3A may be involved. The aim of this study was to evaluate the effect of itraconazole, a CYP3A inhibitor, on the plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients in relation to CYP2D6 genotype. METHODS: Nineteen...

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Source

Identifiers

PMID: 16321618
DOI: 10.1016/j.clpt.2005.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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