Article
A common variant of the p16(INK4a) genetic region is associated with physical function in older people.
Mechanisms of ageing and development - 1 Jan 2000
Melzer David, Frayling Timothy M, Murray Anna, Hurst Alison J, Harries Lorna W, Song Honglin, Khaw Kaytee, Luben Robert, Surtees Paul G, Bandinelli Stefania S, Corsi Anna-Maria, Ferrucci Luigi, Guralnik Jack M, Wallace Robert B, Hattersley Andrew T, Pharoah Paul D
Abstract excerpt
p16(INK4a) is active in cell senescence, ageing and tumor suppression. Deletion of the small p16(INK4a)/ARF/p15(INK4b) region occurs in many cancers. We screened 25 common polymorphisms across the region and three related genes for associations with physical functioning in older people. In an initial sample of 938 (aged 65-80 years) from the EPIC study (Norfolk, UK), the rs2811712 SNP minor allele (located...
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