p16INK4A Influences the Aging Phenotype in the Living Skin Equivalent

Abstract excerpt

human epidermal keratinocyte immunohistochemistry keratin 14 living skin equivalent TO THE EDITOR Senescence is a state wherein cells are metabolically active but are unable to replicate due to the increased expression of cell cycle check point proteins, such as p16INK4A, that prevent passage of cells through the cycle. p16INK4A expression increases significantly in the basal layer of human epidermis and in...

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