Article
QNQKE targeting motif for the SMN-Gemin multiprotein complexin neurons.
Journal of neuroscience research - 1 Sept 2007
Zhang Honglai, Xing Lei, Singer Robert H, Bassell Gary J
Abstract excerpt
Spinal muscular atrophy (SMA) is a heritable neurodegenerative disease affecting motor neurons that is caused by the impaired expression of the full-length form of the survival of motor neuron protein (SMN), which may have a specialized function in neurons related to mRNA localization. We have previously shown that a population SMN complexes contain Gemin ribonucleoproteins and traffic in the form of granules to...
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