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Article

Recurrent disruption of the Imu splice donor site in t(14;18) positive lymphomas: a potential molecular basis for aberrant downstream class switch recombination.

Genes, chromosomes & cancer - 1 Aug 2007

Ruminy Philippe, Jardin Fabrice, Penther Dominique, Picquenot Jean-Michel, Parmentier Françoise, Buchonnet Gérard, Bertrand Philippe, Tilly Hervé, Bastard Christian

Abstract excerpt

t(14;18) positive lymphomas are mature germinal center B-cell neoplasms. In agreement with this cellular origin, most have somatically mutated immunoglobulin variable genes and the IGH@ locus has almost always been reorganized by class switch recombination (CSR). However, contrasting with normal...

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Share to Chromosomes, Human, Pair 14
Share to Chromosomes, Human, Pair 18

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Class Switching

Share to Immunoglobulin Switch Region

Share to Lymphoma, B-Cell

Share to RNA Splice Sites

Share to Sequence Analysis, DNA

Share to Translocation, Genetic

Source

Identifiers

PMID: 17455255
DOI: 10.1002/gcc.20453

Genes

IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17455255-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Recurrent disruption of the Imu splice donor site in t(14;18) positive lymphomas: a potential molecular basis for aberrant downstream class switch recombination.PMID 17455255Read ↗

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