Article
Internal IgH class switch region deletions are position-independent and enhanced by AID expression.
Proceedings of the National Academy of Sciences of the United States of America - 23 Jul 2002
Dudley Darryll D, Manis John P, Zarrin Ali A, Kaylor Lianne, Tian Ming, Alt Frederick W
Abstract excerpt
Ig heavy chain class switch recombination (CSR) involves a recombination/deletion mechanism that exchanges the expressed C(H) gene with a downstream C(H) gene. CSR is mediated by highly repetitive switch (S) region sequences and requires the activation-induced deaminase (AID). The S region 5' of the C mu gene (S mu) can undergo high-frequency internal deletions in normal B cells and B cell lines activated for...
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