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Article

FRA-1 protein overexpression is a feature of hyperplastic and neoplastic breast disorders

25 Jan 2007

Abstract excerpt

BACKGROUND: Fos-related antigen 1 (FRA-1) is an immediate early gene encoding a member of AP-1 family of transcription factors involved in cell proliferation, differentiation, apoptosis, and other biological processes. fra-1 gene overexpression has an important role in the process of cellular transformation, and our previous studies suggest FRA-1 protein detection as a useful tool for the diagnosis of thyroid...

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PMID: 17254320
DOI: 10.1186/1471-2407-7-17

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