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Article

Comprehensive annotation of bidirectional promoters identifies co-regulation among breast and ovarian cancer genes.

PLoS computational biology - 20 Apr 2007

Yang Mary Q, Koehly Laura M, Elnitski Laura L

Abstract excerpt

A "bidirectional gene pair" comprises two adjacent genes whose transcription start sites are neighboring and directed away from each other. The intervening regulatory region is called a "bidirectional promoter." These promoters are often associated with genes that function in DNA repair, with the potential to participate in the development of cancer. No connection between these gene pairs and cancer has been...

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Source

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Identifiers

PMID: 17447839
DOI: 10.1371/journal.pcbi.0030072
PMCID: PMC1853124

Genes

BRCA2
ERBB2
FANCD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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