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Article

Rapid screening mitochondrial DNA mutation by using denaturing high-performance liquid chromatography.

World journal of gastroenterology - 1 Jun 2002

Liu Man-Ran, Pan Kai-Feng, Li Zhen-Fu, Wang Yi, Deng Da-Jun, Zhang Lian, Lu You-Yong

Abstract excerpt

AIM: To optimize conditions of DHPLC and analyze the effectiveness of various DNA polymerases on DHPLC resolution, and evaluate the sensitivity of DHPLC in the mutation screening of mitochondrial DNA (mtDNA). METHODS: Two fragments of 16s gene of mitochondrial DNA (one of them F2 is a mutant fragment) and an A3243G mutated fragment were used to analyze the UV detection limit and determine the minimum percentage...

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Share to Chromatography, High Pressure Liquid
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to MELAS Syndrome

Share to Mitochondrial Encephalomyopathies

Share to Nucleic Acid Denaturation

Share to Stomach Neoplasms

Share to Tumor Cells, Cultured

Source

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Identifiers

PMID: 12046063
DOI: 10.3748/wjg.v8.i3.426
PMCID: PMC4656414

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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