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Article

Serrated adenomas with a BRAF mutation in a young patient with familial adenomatous polyposis.

International journal of colorectal disease - 1 Oct 2020

Moriichi Kentaro, Tanabe Hiroki, Ono Yusuke, Kobayashi Yu, Murakami Yuki, Iwama Takuya, Kunogi Takehito, Sasaki Takahiro, Takahashi Keitaro, Ando Katsuyoshi, Ueno Nobuhiro, Kashima Shin, Takei Hidehiro, Mizukami Yusuke, Fujiya Mikihiro, Okumura Toshikatsu

Abstract excerpt

INTRODUCTION: Familial adenomatous polyposis (FAP) is typically characterized by more than hundred adenomatous polyps in the colorectum, caused by germline APC mutation. A small proportion of the polyps progress to colorectal adenocarcinoma via adenoma-carcinoma sequence. Serrated lesions and polyps, characterized by a serrated architecture of the epithelium, are noted for two types of genetic pathways in...

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PMID: 32504335
DOI: 10.1007/s00384-020-03657-0

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