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Article

Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin.

Cancer research - 15 Mar 2021

Tervonen Topi A, Pant Shishir M, Belitškin Denis, Englund Johanna I, Närhi Katja, Haglund Caj, Kovanen Panu E, Verschuren Emmy W, Klefström Juha

Abstract excerpt

Ras proteins play a causal role in human cancer by activating multiple pathways that promote cancer growth and invasion. However, little is known about how Ras induces the first diagnostic features of invasion in solid tumors, including loss of epithelial integrity and breaching of the basement membrane (BM). In this study, we found that oncogenic Ras strongly promotes the activation of hepsin, a member of the...

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PMID: 33461973
DOI: 10.1158/0008-5472.CAN-20-1760

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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