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Article

Multiple melanomas after treatment for Hodgkin lymphoma in a non-Dutch p16-Leiden mutation carrier with 2 MC1R high-risk variants.

Archives of dermatology - 1 Apr 2007

Figl Adina, Thirumaran Ranjit K, Ugurel Selma, Gast Andreas, Hemminki Kari, Kumar Rajiv, Schadendorf Dirk

Abstract excerpt

BACKGROUND: A 19-base pair germline deletion in exon 2 of the CDKN2A (cyclin-dependent kinase inhibitor 2A) gene (Leiden mutation) has been detected in Dutch families with familial melanomas. The penetrance of CDKN2A mutations varies widely and is influenced by environmental and unrelated genetic...

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Share to Cyclin-Dependent Kinase Inhibitor p16
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Share to Hodgkin Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Loss of Heterozygosity

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Share to Receptor, Melanocortin, Type 1

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Source

Identifiers

PMID: 17438182
DOI: 10.1001/archderm.143.4.495

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17438182-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Multiple melanomas after treatment for Hodgkin lymphoma in a non-Dutch p16-Leiden mutation carrier with 2 MC1R high-risk variants.PMID 17438182Read ↗

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