Article
Genome-wide linkage scan for atypical nevi in p16-Leiden melanoma families.
European journal of human genetics : EJHG - 1 Sept 2008
de Snoo Femke A, Hottenga Jouke-Jan, Gillanders Elizabeth M, Sandkuijl Loudewijk A, Jones Mary Pat, Bergman Wilma, van der Drift Clasine, van Leeuwen Inge, van Mourik Lenny, Huurne Jeanet A C Ter, Frants Rune R, Willemze Rein, Breuning Martijn H, Trent Jeffrey M, Gruis Nelleke A
Abstract excerpt
In most Dutch melanoma families, a founder deletion in the melanoma susceptibility gene CDKN2A (which encodes p16) is present. This founder deletion (p16-Leiden) accounts for a significant proportion of the increased melanoma risk. However, it does not account for the Atypical Nevus (AN) phenotype that segregates in both p16-Leiden carriers and non-carriers. The AN-affected p16-Leiden family members are therefore...
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