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Article

[Biallelic inactivation of the p16-Gen in a metachronous triple carcinoma in the oropharyngeal region].

Laryngo- rhino- otologie - 1 Jan 2004

Motsch C, Giers A, Boltze C, Evert M, Freigang B, Roessner A, Schneider-Stock R

Abstract excerpt

AIMS: Recent studies have shown that most Dutch families with atypical multiple-mole melanoma (FAMMM) have a 19-bp deletion (p16-Leiden) in exon 2 of the p16 gene. Apart from reports on metachronous pancreatic tumors, other cancer types have never been described in such families. Due to heterozygous p16-Leiden constitution, our proband with multiple head and neck carcinomas was a suitable model for studying the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 14740307
DOI: 10.1055/s-2004-814111

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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[Biallelic inactivation of the p16-Gen in a metachronous triple carcinoma in the oropharyngeal region].PMID 14740307Read ↗

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Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 (p16-Leiden).Semantic proximity Read ↗

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