Article
Surveillance of second-degree relatives from melanoma families with a CDKN2A germline mutation.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2013
van der Rhee Jasper I, Boonk Stephanie E, Putter Hein, Cannegieter Suzanne C, Flinterman Linda E, Hes Frederik J, de Snoo Femke A, Mooi Wolter J, Gruis Nelleke A, Vasen Hans F A, Kukutsch Nicole A, Bergman Wilma
Abstract excerpt
BACKGROUND: Lifetime melanoma risk of mutation carriers from families with a germline mutation in the CDKN2A gene is estimated to be 67%. The necessity to include family members in a melanoma surveillance program is widely endorsed, but there is no consensus on which family members should be invited. METHODS: In a retrospective follow-up study, we investigated the yield of surveillance of first- and second-degree...
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