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Novel Mutation of Human DNA Polymerase γ Associated with Mitochondrial Toxicity Induced by Anti‐HIV Treatment

17 Apr 2007

Abstract excerpt

Mitochondrial toxicity is a major adverse effect of the nucleoside reverse-transcriptase inhibitors (NRTIs) used for treatment of human immunodeficiency virus type 1 (HIV-1) infection and can result in life-threatening lactic acidosis. The toxicity is due to inhibition of polymerase gamma (Pol gamma), which is required for replication of mitochondrial DNA (mtDNA). Genetic factors could be involved in this...

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PMID: 17436221
DOI: 10.1086/513872

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