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Article

Polymorphisms in DNA polymerase γ affect the mtDNA stability and the NRTI-induced mitochondrial toxicity in Saccharomyces cerevisiae.

Mitochondrion - 1 Jan 2015

Baruffini Enrico, Ferrari Jessica, Dallabona Cristina, Donnini Claudia, Lodi Tiziana

Abstract excerpt

Several pathological mutations have been identified in human POLG gene, encoding for the catalytic subunit of Pol γ, the solely mitochondrial replicase in animals and fungi. However, little is known regarding non-pathological polymorphisms found in this gene. Here we studied, in the yeast model S...

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Identifiers

PMID: 25462018
DOI: 10.1016/j.mito.2014.11.003
PMCID: PMC4309887

Genes

POLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25462018-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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