Article
Proteinase-activated receptor 4 stimulation-induced epithelial-mesenchymal transition in alveolar epithelial cells.
Respiratory research - 16 Apr 2007
Ando Seijitsu, Otani Hitomi, Yagi Yasuhiro, Kawai Kenzo, Araki Hiromasa, Fukuhara Shirou, Inagaki Chiyoko
Abstract excerpt
BACKGROUND: Proteinase-activated receptors (PARs; PAR1-4) that can be activated by serine proteinases such as thrombin and neutrophil catepsin G are known to contribute to the pathogenesis of various pulmonary diseases including fibrosis. Among these PARs, especially PAR4, a newly identified subt...
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