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Article

Proteinase-activated receptor 4 stimulation-induced epithelial-mesenchymal transition in alveolar epithelial cells.

Respiratory research - 16 Apr 2007

Ando Seijitsu, Otani Hitomi, Yagi Yasuhiro, Kawai Kenzo, Araki Hiromasa, Fukuhara Shirou, Inagaki Chiyoko

Abstract excerpt

BACKGROUND: Proteinase-activated receptors (PARs; PAR1-4) that can be activated by serine proteinases such as thrombin and neutrophil catepsin G are known to contribute to the pathogenesis of various pulmonary diseases including fibrosis. Among these PARs, especially PAR4, a newly identified subtype, is highly expressed in the lung. Here, we examined whether PAR4 stimulation plays a role in the formation of...

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Source

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Identifiers

PMID: 17433115
DOI: 10.1186/1465-9921-8-31
PMCID: PMC1855055

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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