Article
Down-regulation of protease-activated receptor 4 in lung adenocarcinoma is associated with a more aggressive phenotype.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013
Jiang Ping, Yu Guo-Yu, Zhang Yong, Xiang Yang, Hua Hai-Rong, Bian Li, Wang Chun-Yan, Lee Wen-Hui, Zhang Yun
Abstract excerpt
The role of protease-activated receptors (PARs) in lung tumors is controversial. Although PAR4 is preferentially expressed in human lung tissues, its possible significance in lung cancer has not been defined. The studies reported herein used a combination of clinical observations and molecular methods. Surgically resected lung adenocarcinomas and associated adjacent normal lung tissues were collected and BEAS-2B...
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